Design, Synthesis of N-(Substituted Imidazo [1, 2-b] Pyridazine) Acetamides and Their Anti-Proliferative Studies on BRAFV600E Mutated A375 and Colo-205 Cell Lines.
نویسندگان
چکیده
منابع مشابه
SYNTHESIS OF SOME IMIDAZO [ I , 2-b] [l , 2,4] TRIAZINE AND N-ALKYLATED IMIDAZO [l , 2-b] [1 , 2,4]-TRIAZINES
A number of 3-amino-1, 2, 4-triazin-5 (2H)- ones(1) were synthesized and condensed with a-haloketones to give 2,6-disubstituted imidazo [1, 2-b] [1, 2, 4]-triazin-3 (4H)-ones (2). These compounds were reacted further with a - haloketones to yield N-alkylated products (3).
متن کاملsynthesis of some imidazo [ i , 2-b] [l , 2,4] triazine and n-alkylated imidazo [l , 2-b] [1 , 2,4]-triazines
a number of 3-amino-1, 2, 4-triazin-5 (2h)- ones(1) were synthesized and condensed with a-haloketones to give 2,6-disubstituted imidazo [1, 2-b] [1, 2, 4]-triazin-3 (4h)-ones (2). these compounds were reacted further with a - haloketones to yield n-alkylated products (3).
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1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines.
The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumor cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma) were evaluated, and discussed in terms of structure-activity relationship.
متن کاملsingle-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...
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ژورنال
عنوان ژورنال: IOSR Journal of Pharmacy and Biological Sciences
سال: 2017
ISSN: 2319-7676,2278-3008
DOI: 10.9790/3008-1203048491